Ira Tabas Selected Research

Obesity

1/2020	Interacting hepatic PAI-1/tPA gene regulatory pathways influence impaired fibrinolysis severity in obesity.
1/2018	Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance.
1/2016	Hepatocyte DACH1 Is Increased in Obesity via Nuclear Exclusion of HDAC4 and Promotes Hepatic Insulin Resistance.
10/2015	Treatment of Obese Insulin-Resistant Mice With an Allosteric MAPKAPK2/3 Inhibitor Lowers Blood Glucose and Improves Insulin Sensitivity.
12/2013	Activation of calcium/calmodulin-dependent protein kinase II in obesity mediates suppression of hepatic insulin signaling.
5/2012	Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity.
5/2012	Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice.
11/2009	Defective phagocytosis of apoptotic cells by macrophages in atherosclerotic lesions of ob/ob mice and reversal by a fish oil diet.
12/2008	Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism.
3/2004	Increased CD36 protein as a response to defective insulin signaling in macrophages.

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Ira Tabas Research Topics

Disease

64	Atherosclerosis 11/2023 - 04/2002
29	Inflammation (Inflammations) 11/2023 - 04/2002
20	Necrosis 11/2023 - 11/2002
16	Atherosclerotic Plaque (Atheroma) 01/2022 - 02/2004
12	Insulin Resistance 01/2021 - 11/2007
11	Cardiovascular Diseases (Cardiovascular Disease) 11/2023 - 05/2006
10	Obesity 01/2020 - 03/2004
8	Fibrosis (Cirrhosis) 05/2023 - 12/2016
8	Peritonitis 01/2022 - 04/2013
6	Type 2 Diabetes Mellitus (MODY) 01/2018 - 11/2008
5	Liver Cirrhosis (Hepatic Cirrhosis) 12/2023 - 01/2020
5	Thrombosis (Thrombus) 01/2020 - 11/2006
4	Hypercholesterolemia 11/2023 - 05/2005
4	Non-alcoholic Fatty Liver Disease 01/2021 - 11/2018
4	Coronary Artery Disease (Coronary Atherosclerosis) 05/2012 - 08/2005
3	Myocardial Infarction 01/2021 - 03/2010
3	Porcine Reproductive and Respiratory Syndrome (PRRS) 09/2009 - 12/2006
2	Neoplasms (Cancer) 01/2023 - 04/2022
2	Liver Diseases (Liver Disease) 10/2022 - 01/2022
2	Pathologic Processes 04/2022 - 01/2017
2	Myocardial Ischemia (Ischemic Heart Diseases) 01/2021 - 09/2017
2	Infarction (Infarctions) 01/2021 - 09/2017
2	Disease Progression 01/2018 - 09/2009
2	Reperfusion Injury 09/2017 - 04/2013
2	Infections 01/2016 - 03/2014
2	Hyperglycemia 01/2016 - 10/2015
2	Hyperlipidemias (Hyperlipidemia) 02/2013 - 05/2008
2	Coronary Disease (Coronary Heart Disease) 03/2010 - 05/2006
2	Sitosterolemia 01/2007 - 11/2006
2	Vascular Diseases (Vascular Disease) 01/2007 - 11/2006

Drug/Important Bio-Agent (IBA)

25	CholesterolIBA 11/2023 - 11/2002
16	Lipoproteins (Lipoprotein)IBA 01/2023 - 04/2002
15	c-Mer Tyrosine KinaseIBA 01/2023 - 08/2008
13	LipidsIBA 01/2020 - 02/2004
12	Proteins (Proteins, Gene)FDA Link 11/2023 - 12/2008
11	Insulin (Novolin)FDA Link 01/2016 - 03/2004
7	CytokinesIBA 10/2022 - 04/2002
7	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2018 - 10/2009
6	ApolipoproteinsIBA 01/2023 - 10/2007
6	Apolipoproteins E (ApoE)IBA 05/2014 - 08/2008
5	ZymosanIBA 12/2021 - 04/2013
5	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 04/2012
4	Apolipoproteins B (ApoB)IBA 01/2023 - 08/2005
4	RNA (Ribonucleic Acid)IBA 01/2022 - 09/2019
4	Small Interfering RNA (siRNA)IBA 01/2022 - 01/2016
4	LDL Receptors (LDL Receptor)IBA 03/2012 - 11/2003
4	Pattern Recognition ReceptorsIBA 09/2011 - 12/2006
3	Dexamethasone (Maxidex)FDA LinkGeneric 11/2023 - 12/2021
3	EnzymesIBA 04/2022 - 09/2010
3	Triglycerides (Triacylglycerol)IBA 01/2021 - 03/2010
3	CollagenIBA 01/2018 - 04/2013
3	Peptides (Polypeptides)IBA 02/2015 - 08/2005
3	LDL Lipoproteins (beta Lipoproteins)IBA 01/2015 - 04/2005
3	CalciumIBA 12/2013 - 05/2006
3	PPAR gammaIBA 06/2010 - 03/2004
2	Interleukin-6 (Interleukin 6)IBA 06/2023 - 06/2005
2	Biomarkers (Surrogate Marker)IBA 05/2023 - 09/2017
2	Calcium-Calmodulin-Dependent Protein KinasesIBA 01/2022 - 12/2013
2	PutrescineIBA 01/2021 - 01/2020
2	MAP-kinase-activated kinase 2IBA 01/2021 - 10/2015
2	LigandsIBA 01/2021 - 06/2017
2	Interleukin-10 (Interleukin 10)IBA 01/2021 - 01/2016
2	Antisense OligonucleotidesIBA 01/2021 - 11/2018
2	LeukotrienesIBA 01/2019 - 09/2016
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2018 - 06/2017
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 09/2017 - 06/2016
2	Transcription Factor CHOPIBA 05/2015 - 09/2010
2	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 01/2015 - 05/2014
2	Phosphotransferases (Kinase)IBA 12/2013 - 06/2005
2	Transcription Factors (Transcription Factor)IBA 03/2012 - 12/2011
2	SphingomyelinsIBA 03/2010 - 05/2006
2	Insulin ReceptorIBA 01/2010 - 04/2006
2	AcidsIBA 10/2008 - 04/2005
1	Deubiquitinating EnzymesIBA 11/2023
1	holomycinIBA 11/2023
1	InflammasomesIBA 11/2023
1	Mitogen-Activated Protein Kinase 8IBA 11/2023
1	pexidartinibIBA 06/2023
1	Interleukin-6 Receptors (Interleukin 6 Receptor)IBA 06/2023
1	Macrophage Colony-Stimulating FactorIBA 06/2023
1	Indicators and Reagents (Reagents)IBA 05/2023
1	KinesinsIBA 01/2023
1	Programmed Cell Death 1 ReceptorIBA 01/2023
1	Sorafenib (BAY 43-9006)FDA Link 01/2023
1	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 01/2023
1	DNA (Deoxyribonucleic Acid)IBA 04/2022
1	NADP (NADPH)IBA 04/2022
1	8-hydroxyguanineIBA 04/2022
1	DNA Repair EnzymesIBA 04/2022
1	Dinoprostone (PGE2)FDA Link 01/2022
1	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2022
1	Platelet-Derived Growth FactorIBA 01/2022
1	nasIBA 01/2021
1	AcetylgalactosamineIBA 01/2021
1	PalmitatesIBA 01/2021
1	Axl Receptor Tyrosine KinaseIBA 01/2021
1	Ornithine Decarboxylase (Decarboxylase, Ornithine)IBA 01/2021
1	Mitogen-Activated Protein KinasesIBA 01/2021

Therapy/Procedure

18	Therapeutics 12/2023 - 10/2007
2	Drug Therapy (Chemotherapy) 01/2021 - 11/2018